Cinnamaldehyde Decreases the Pathogenesis of Aeromonas hydrophila by Inhibiting Quorum Sensing and Biofilm Formation
نویسندگان
چکیده
Antibiotics were the main fishery drugs for treating Aeromonas hydrophila (A. hydrophila) infection, which would generate selective pressure and result in appearance of antibiotic-resistant bacteria. The bacterial quorum sensing (QS) system provides a new alternative strategy against A. infection. QS inhibitors can reduce virulence behaviors by disrupting QS, has no effect on growth. Therefore, we studied cinnamaldehyde from natural plant extract aiming to its pathogenicity. efficacy was evaluated various aspects, including effects aerolysin, lipase, protease, swarming motility, biofilm formation, acyl-homoserine lactones (AHLs), QS-related genes. Moreover, therapeutic vitro vivo studied. results showed that could decrease phenotypes regulated QS. transcriptions related genes (aerA, ahyR, ahyI) downregulated following addition cinnamaldehyde. assays show aerolysin-mediated A549 cell injury increase survival rate crucian carp infected with hydrophila. These indicate be candidate inhibitor
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ژورنال
عنوان ژورنال: Fishes
سال: 2023
ISSN: ['2410-3888']
DOI: https://doi.org/10.3390/fishes8030122